Fig. 5. p53 expression is drastically induced in embryonic MDM2-deleted endocrine pancreatic progenitors and in endocrine pancreatic cells of adult MDMX-deleted mice. A).
Representative images of co-immunostaining with anti-p53 (red) and anti-PDX1 (green) antibodies on cryo-sections of E13.5 and E15.5 MDM2-knockout and control embryonic pancreas. B) Representative images of co-immunostaining with anti-p53 (red) and anti-PDX1 (green) antibodies on pancreas cryo-sections of 1-week-old MDMX-knockout and control mice.