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. 2017 Feb 28;10:49. doi: 10.3389/fnmol.2017.00049

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Copyright © 2017 Xue, Shi, Chen, Hang, Xia, Wu, Tao, Zhou, Shi and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Melatonin suppressed KA-induced ER stress in vivo. (A) Expression of GRP78, CHOP and calpain in KA and/or melatonin-treated animals hippocampus. (B) Relative analysis of the expression levels of GRP78, CHOP and calpain in KA and/or melatonin-treated animals hippocampus. (C) Relative activity of calpain in KA and/or melatonin-treated animals hippocampus. ^∗∗P < 0.01, ^∗∗∗P < 0.001 vs. controls; ^#P < 0.05, ^##P < 0.01 vs. the KA group; significant difference from the respective values determined by one-way analysis of variance test. n = 3 for western blots; n = 5 for calpain activity assay.