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Structural similarities between Major Histocompatibility Complex (MHC) class I and II molecules with MICA. The latter is equivalent to the heavy chain of MHC class I molecule without the β2 microglobulin. While the MHC I and II present peptides to CD8 and CD4 cells, respectively, the MICA recognizes NKG2D receptors on the surface of natural killer (NK) cells.
