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. 2017 Feb 28;11:92. doi: 10.3389/fnins.2017.00092

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Copyright © 2017 Yang, Kuc, Brame, Dyson, Singer, Glen, Cheriyan, Wilkinson, Davenport and Maguire.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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[Pyr¹]apelin-13_(1–12) binds to and activates the human apelin receptor. (A) Competition binding curve for [Pyr¹]apelin-13 () and [Pyr¹]apelin-13_(1–12) () in human left ventricle (n = 3). In cell based assays [Pyr¹]apelin-13 (), [Pyr¹]apelin-13_(1–12) (), and apelin-17 () (B) inhibited forskolin-stimulated cAMP production; (C) induced β-arrestin recruitment and (D) triggered apelin receptor internalization.

Inline graphic — [Pyr¹]apelin-13_(1–12) binds to and activates the human apelin receptor. (A) Competition binding curve for [Pyr¹]apelin-13 () and [Pyr¹]apelin-13_(1–12) () in human left ventricle (n = 3). In cell based assays [Pyr¹]apelin-13 (), [Pyr¹]apelin-13_(1–12) (), and apelin-17 () (B) inhibited forskolin-stimulated cAMP production; (C) induced β-arrestin recruitment and (D) triggered apelin receptor internalization.