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. 2017 Feb 28;11:92. doi: 10.3389/fnins.2017.00092

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Copyright © 2017 Yang, Kuc, Brame, Dyson, Singer, Glen, Cheriyan, Wilkinson, Davenport and Maguire.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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In vivo actions of [Pyr¹]apelin-13_(1–12) in human volunteers. Infusion of [Pyr¹]apelin-13_(1–12) in healthy human volunteers (, n = 12) resulted in a dose-dependent increase in forearm blood flow. Significantly different from baseline; ^*P < 0.05, ^**P < 0.01. One-way ANOVA repeated measures compared to baseline with Dunnett's multiple comparison test.

Inline graphic — In vivo actions of [Pyr¹]apelin-13_(1–12) in human volunteers. Infusion of [Pyr¹]apelin-13_(1–12) in healthy human volunteers (, n = 12) resulted in a dose-dependent increase in forearm blood flow. Significantly different from baseline; ^*P < 0.05, ^**P < 0.01. One-way ANOVA repeated measures compared to baseline with Dunnett's multiple comparison test.