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. 2017 Feb 28;8:94. doi: 10.3389/fphar.2017.00094

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Copyright © 2017 Foote, Behe, Frampton, Levine and Segal.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Vacuolar pH (A) and area (B) measured in the single knockout CLIC1^-/- mice, and in the double knockout HVCN1^-/-/CLIC1^-/- mice. Each square represents an individual measurement with an overlaying boxplot showing the median and interquartile range. The SFR cut-off value for the HVCN1^-/- and double knockout mice was 2.20. Difference between HVCN1^-/- and HVCN1^-/-/CLIC1^-/-: ^∗∗∗p < 0.001.