Figure 1.

Schematic diagram showing the methods used to generate induced pluripotent stem cells (iPSCs) from human somatic cells as skin fibroblasts or blood cells. The hiPSCs derived from a patient carrying a certain genetic mutation in a neurodegenerative disease have the capacity to differentiate into different neurons. Those patient-specific hiPSCs and hiPS-derived neurons can be expanded and further differentiated into mature neural subtypes specific to certain neurodegenerative diseases.