Table 1.

Treatment modalities

Author	Number of patients	Treatment modality	Treatment duration
Goulden et al. (1997) [16]	80	Isotretinoin 0.5 mg/kg/day during 7 days and 3-week break	6 months
Kaymak et al. (2006) [17]	60	Isotretinoin 0.75 mg/kg/day during 7 days and 3-week break Isotretinoin 0.6 mg/kg/day during 7 days and 3-week break Isotretinoin 0.5 mg/kg/day during 7 days and 3-week break	6 months
Akman et al. (2007) [18] randomized, controlled, multicenter study	66	Isotretinoin 0.5 mg/kg/day during 10 days of each month Isotretinoin 0.5 mg/kg/day each day in the first month and 10 days of each month for 5 months Isotretinoin 0.5 mg/kg/day every day	6 months
Mandekou-Lefaki et al. (2003) [19]	64	Isotretinoin 0.15–0.40 mg/kg/day Isotretinoin 0.5–1.0 mg/kg/day	Total dose up to 120 mg/kg
Amichai et al. (2006) [20]	638	Isotretinoin 20 mg/day (0.3–0.4 mg/kg/day)	6 months
Sardana et al. (2009) [21]	320	Isotretinoin 20 mg/day every other day (0.15–0.28 mg/kg/day)	6 months
Lee et al. (2011) [22] randomized, controlled study	60	Isotretinoin 0.5–0.7 mg/kg/day Isotretinoin 0.25–0.4 mg/kg/day Isotretinoin 0.5–0.7 mg/kg/day during 7 days and 3-week break	6 months
Rasi et al. (2014) [23]	140	Isotretinoin 20 mg/day	Up to cumulative dose of 120 mg/kg
Kotori (2015) [24]	50	Isotretinoin 20 mg/day	3 months
Rademaker et al. (2014) [25] randomized, double-blind, placebo-controlled study	60	Isotretinoin 5 mg/day	16 weeks