Table 1.
Summary of associations between genetic variants at 9p21.3 and esophageal squamous cell carcinoma risk in 2139 cases and 2273 controls in a Chinese population
| SNP | Cases, n (%) | Controls, n (%) | OR (95% CI)a | P‐valuea |
|---|---|---|---|---|
| rs7023329 | n = 2121 | n = 2239 | ||
| AA | 706 (33.29) | 576 (25.73) | 1.00 (reference) | |
| AG | 950 (44.79) | 1129 (50.42) | 0.68 (0.59–0.79) | 1.47 × 10−7 |
| GG | 465 (21.92) | 534 (23.85) | 0.72 (0.61–0.85) | 1.12 × 10−4 |
| G allele | 0.84 (0.77–0.91) | 2.95 × 10−5 | ||
| rs3731239 | n = 2095 | n = 2235 | ||
| TT | 1572 (75.04) | 1697 (75.93) | 1.00 (reference) | |
| TC | 498 (23.77) | 503 (22.51) | 1.12 (0.97–1.29) | 0.118 |
| CC | 25 (1.19) | 35 (1.75) | 0.76 (0.45–1.18) | 0.312 |
| C allele | 0.96 (0.84–1.10) | 0.581 | ||
| rs3731217 | n = 2058 | n = 2224 | ||
| TT | 1325 (64.38) | 1421 (63.89) | 1.00 (reference) | |
| TG | 641 (31.15) | 715 (32.15) | 0.95 (0.83–1.08) | 0.423 |
| GG | 92 (4.47) | 88 (3.96) | 1.13 (0.83–1.53) | 0.432 |
| G allele | 0.99 (0.89–1.11) | 0.909 | ||
| rs1011970 | n = 2088 | n = 2227 | ||
| GG | 1745 (83.57) | 1835 (82.40) | 1.00 (reference) | |
| GT | 331 (15.85) | 381 (17.11) | 0.88 (0.75–1.03) | 0.112 |
| TT | 12 (0.57) | 11 (0.49) | 1.20 (0.52–2.75) | 0.667 |
| T allele | 0.90 (0.77–1.05) | 0.183 | ||
| rs1679013 | n = 2130 | n = 2182 | ||
| TT | 1247 (58.54) | 1366 (62.60) | 1.00 (reference) | |
| TC | 778 (36.53) | 739 (33.87) | 1.07 (0.94–1.21) | 0.322 |
| CC | 105 (4.93) | 77 (3.53) | 1.44 (1.06–1.96) | 0.020 |
| C allele | 1.12 (1.01–1.24) | 0.039 |
a
Derived from logistic regression with an adjustment for age, sex, and smoking and drinking status. CI, confidence interval; OR, odds ratio.