Table 3.
Results of univariate and multivariate analysis for overall survival
| Variable | Category | Hazard ratio for death (95.0% CI) | P‐value |
|---|---|---|---|
| Univariate analysis | |||
| Age (years) | < 60 vs ≥ 60 | 1.402 (0.690–2.850) | 0.351 |
| Gender | Male vs Female | 0.754 (0.365–1.555) | 0.444 |
| Smoking | Non–smoker vs Smoker | 0.992 (0.472–2.086) | 0.984 |
| Alcohol | No alcohol use vs Alcohol use | 1.058 (0.463–2.418) | 0.893 |
| Subsite | Tongue/Gum vs Others (BM/FOM/HP) | 2.711 (1.289–5.700) | 0.009 |
| Histological differentiation | Well/Moderately vs Poorly | 2.014 (0.874–4.643) | 0.100 |
| cStage | cStage I–III vs cStage IV | 1.901 (0.953–3.792) | 0.068 |
| Stage | Stage I–III vs Stage IV | 6.505 (2.822–14.99) | <0.001 |
| RTK | No amplification vs Amplification | 2.662 (1.290–5.491) | 0.008 |
| PIK3CA | No amplification vs Amplification | 0.543 (0.166–1.781) | 0.314 |
| Wild type vs Mutation | 1.197 (0.365–3.925) | 0.767 | |
| RAS/RAF pathway | No amplification vs Amplification | 0.731 (0.175–3.057) | 0.668 |
| Wild type vs Mutation | 0.901 (0.123–6.599) | 0.918 | |
| CDKN2A | No deletion vs Deletion | 2.442 (1.059–5.634) | 0.036 |
| Wild type vs Mutation | 0.874 (0.337–2.264) | 0.781 | |
| TP53 | No deletion vs Deletion | 1.375 (0.419–4.510) | 0.599 |
| Wild type vs Mutation | 1.192 (0.593–2.397) | 0.622 | |
| Multivariate analysis | |||
| Age (years) | < 60 vs ≥ 60 | 1.256 (0.595–2.653) | 0.550 |
| Subsite | Tongue/Gum vs Others (BM/FOM/HP) | 2.170 (0.958–4.918) | 0.063 |
| Histological differentiation | Well/Moderately vs Poorly | 2.176 (0.917–5.162) | 0.078 |
| cStage | cStage I–III vs cStage IV | 1.824 (0.879–3.788) | 0.107 |
| RTK | No amplification vs Amplification | 2.410 (1.056–5.498) | 0.037 |
| CDKN2A | No deletion vs Deletion | 1.104 (0.398–3.059) | 0.849 |
RTK (EGFR, ERBB2, ERBB4, FGFR1, FGFR2, FGFR3, FLT3, KIT, MET, PDGFRA). RAS‐RAF pathway (BRAF, HRAS, KRAS, NRAS). BM, buccal mucosa; cStage, clinical stage; FOM, floor of mouth; HP, hard palate.