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. Author manuscript; available in PMC: 2018 Jul 1.
Published in final edited form as: Bone. 2016 Aug 27;100:94–99. doi: 10.1016/j.bone.2016.08.022

Table 1.

Is it hypercalcemia or increased calcium intake that matters?

Treatment “clinical”
Scenario		 Thoracic
calcification		 Heart
calcification		 Valve
calcification
None (control
CKD animals)		 SHPT
High phosph, nl
Ca		 ↔ ↔ ↔
R-568 Controlled PTH
High phosph
Low calcium		 ↔ ↓ ↓ ↓ ↓
R-568 + calcium Controlled PTH
Normal phosph
Normal calcium
*calcium load		 ↔ ↑ ↑ ↑ ↔ ↑
Calcium alone Controlled PTH
Normal phosph
High calcium
*hypercalcemia
and calcium load		 ↔ ↑ ↑ ↑ ↔ ↑

Studies utilizing advanced stage CKD rats treated as in the first column. SHPT = secondary hyperparathyroidism; PTH = parathyroid, phosph = phosphorus. Arrows represent increase or decrease compared to control CKD animals. Adapted from [34]