Table 3.
Effect of treatment with ethanol extract of Homalium letestui stem on hematological parameters of rats with paracetamol-induced hepato-nephrotoxicity
|
Parameters
Treatment Dose (m g /kg) |
RBC
(X 10 12 /l) |
PCV
(%) |
Hb
(g/dl) |
WBC
(X 10 9 /l) |
Neutrophils
(%) |
Lymphocytes
(%) |
Monocytes
(%) |
Eosinophils
(%) |
Basophils
(%) |
Platelet |
|---|---|---|---|---|---|---|---|---|---|---|
| Control | 7.920.19 | 44.09.90 | 13.460.16 | 17.082.12 | 29.361.71 | 48.138.67 | 3.131.19 | 2.160.79 | 2.200.40 | 700.338.93 |
|
PCM +
Dist. water |
7.750.55 | 43.02.00 | 13.210.31 | 16.342.18 | 24.578.71 | 21.2413.32c | 2.501.30 | 1.170.97 a | 0.20.20c | 665.315.31c |
| HL.250 + PCM | 8.050.41 | 48.02.10 | 13.900.48 | 14.401.85 | 23.955.48 | 54.7011.24 b | 2.381.30 | 2.501.05c,e | 0.000.00 c | 817.38.50cf |
| HL.500 + PCM | 7.410.46 | 44.01.00 | 12.510.25 | 11.431.17 | 32.379.82 | 23.5012.05 c | 4.620.50c,f | 2.171.10c,e | 0.000.00cf | 908.598.94cf |
| HL.750 + PCM | 8.020.28 | 46.01.17 | 13.380.40 | 10.321.88 | 20.369.05 | 24.1110.86 b | 3.672.00c,e | 2.341.17 a | 0.000.00cf | 640.346.10c |
| Silymarin 100 + PCM | 7.570.20 | 44.21.16 | 13.500.35 | 11.661.54 | 16.597.88b,f | 21.8710.07 e | 0.500.02 c | 1.510.70c,e | 0.000.00cf | 547.526.62cf |
Data were expressed as mean±SEM. Significant at ap< 0.05, bp< 0.01 and cp< 0.001 when compared to control. Significant at dp< 0.05, ep< 0.01 and fp< 0.001 when compared to paracetamol. PCM : paracetamol; HL: Homalium letestui. n = 6.