Table 1.
Inhibition percentage of different extracts of Marrubium astracanicum aerial parts in formalin test
| Groups (n=6) | Dose (mg/kg) | Inhibition percentage (%) | |
|---|---|---|---|
| Acute phase | Chronic phase | ||
| Total extract | 50 | 38.03±5.2 **** | 6.21±4.29 #### |
| 100 | 46.83±3.59 *** | 10.83±8.85 #### | |
| 200 | 45.03±6.17 **** | 17.58±7.55 #### | |
| n-Hexane fraction | 50 | 1.85±6.71 #### | 66.78±3.05 **** |
| 100 | 9.98±12.07 ### | 75.37±7.26 **** | |
| 200 | 23.02±13.10 | 79.92±6.12 **** | |
| Residual fraction | 50 | 9.4±15.2 ### | 75.07±8.67 **** |
| 100 | 23.5±12.65 | 80.10±9.11 **** | |
| 200 | 25.63±14.22 | 80.63±4.02 **** | |
| Morphine | 5 | 39.99±3.25 | 71.58±2.98 |
Different doses of all extracts were administered intraperitoneally to mice, 30 min before intraplantar injection of formalin. Antinociception was recorded 0-5 min (acute phase) and 15-60 min (chronic phase) after formalin injection. Values are mean±S.D. for each group of six mice.
*
p<0.05,
**
p<0.01,
***
p<0.001,
****
p<0.0001 (as compared to acute or chronic phase),
#
p<0.05,
##
p<0.01,
###
p<0.001
####
p<0.0001 (as compared to morphine 5 mg/kg).