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. 2017 Feb 14;2017:7346103. doi: 10.1155/2017/7346103

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Copyright © 2017 Yi Sun et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Effects of hPPE-hBMSCs on proinflammatory cytokine levels in the spinal cords of rats with bone cancer pain (BCP) were compared by enzyme-linked immunosorbent assay (ELISA). After treatment with cell transplantation for 3 d following BCP operation, the spinal cords were homogenized and the IL-1β (a) and IL-6 (b) levels were measured. Normal, the normal group; BCP + saline, the BCP group; BCP + pBABE-hBMSCs, the BCP + pBABE-hBMSC group; BCP + hPPE-hBMSCs, the BCP + hPPE-hBMSC group. Data were expressed as the mean ± SEM. n = 6. Statistical analysis was performed by one-way analysis of variance followed by the least-significant difference or Dunnett T3 test. ^∗P < 0.01 versus the normal group; ^#P < 0.05 versus the BCP + saline group. hPPE, human proenkephalin; pBABE, a retroviral vector; hBMSCs, human bone marrow stem cells.