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. 2017 Feb 26;9(2):37–44. doi: 10.4252/wjsc.v9.i2.37

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©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.

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Potential mechanisms on how CD8⁺ T cells improve hematopoietic stem and progenitor cells engraftment. The following modes of action have been described or suggested by which donor T cells can support the engraftment of HSPCs upon transplantation: (1) killing of residual host HSPCs; (2) killing of residual host T cells; (3) augmented homing of HSPCs to CXCL12 produced by reticular SC or MSCs; (4) increased HSPC differentiation by IFN-γ-induced production of IL-6 by MSCs. HSPCs: Hematopoietic stem and progenitor cells; SC: Stromal cells; MSCs: Mesenchymal stromal cells; IFN-γ: Interferon-gamma; IL-6: Interleukin-6.