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. Author manuscript; available in PMC: 2017 Feb 28.
Published in final edited form as: Wiley Interdiscip Rev Syst Biol Med. 2012 May 17;4(4):401–412. doi: 10.1002/wsbm.1172

Figure 2.

Figure 2

Evidence for a transcriptional tug-of-war underlying sex determination. A coexpression network was estimated for a subset of 40 genes quantified in 68 XY gonad samples from a mixed F2 intercross of B6 and 129S1. ‘Male’ genes that are enriched in XY gonads at E11.5 are highlighted in blue, whereas ‘female’-enriched genes are highlighted in pink, and genes with known roles in sex determination that are not expressed in a sexually-dimorphic pattern at E11.5 are highlighted in yellow. Thick black edges represent more robust coexpression relationships (partial correlation coefficient ≥ 0.33), while thinner edges are less robust but still significant (partial correlation coefficient ≥ 0.25).

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