Table 1.

PNAs as anti-miRNA agents.

Target	PNA modification	System Cellular/animal	Effect	Ref
miR-122	K-PNA-K3	-human hepatocellular carcinoma cells -primary rat hepatocytes	Decrease in miR-122 and mRNA of its target genes. (Aldolase A)	14
miR-16	RRRQRRKKR-O-PNA	HeLa cells	Upregulation of bcl-2 mRNA levels	55
miR-21	RRRQRRKKR-O-PNA	HeLa cells	Upregulation of mRNA targets measured by luciferase assay	55
miR-24	RRRQRRKKR-O-PNA	HeLa cells	Upregulation of mRNA targets measured by luciferase assay	55
miR-155	K-PNA-K3	LPS-activated primary B cells and mice	Up-regulation of 724 transcripts	56
miR-155	PLGA NP coated with R9 -PNA	KB cells	Decrease in miR-155 and mRNA	57
miR-155	RQIKIWFQNRRMKWKK-PNA	Mouse model of Lymphoma	Decrease in miR-155 SHIP1 repression	58
miR-210	R8-PNA	K562 chronic myelogenous leukemia cells	Alterations of erythroid differentation	62
miR-221	R8-PNA	Breast cancer cells	Upregulation of p27kip1 gene expression	63
miR-375	RRRQRRKKR-PNA	Limb mesenchymal cell	Increase Migration of chondrogenic progenitors Expression level of Cadherin 7	64
miR-210	γ-GPNA	K562 leukemic cells	Alterations of erythroid differentation	123