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. 2017 Feb 28;10:59. doi: 10.1186/s13045-017-0424-0

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 6 — Downregulation of ERK3 rescues ICC cell survival in cells treated with both metformin and ATO. a Downregulation of AMPK by specific siRNAs partially rescued ICC cell survival in cells treated with metformin and ATO (^* P < 0.05). b The expression level of ERK3 was detected by western blot in ICC cells after MAPK6-specific siRNA interference