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. 2017 Feb 28;18:131. doi: 10.1186/s12859-017-1558-3

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Drug similarity-based classification results: AUC values for drug-similarity-based classifications based on the drug-signaling pathway similarity and traditional drug-similarity measures. Drug-signaling pathway similarity includes the gene component similarity (Gene-Sim), gene ontology enrichment similarity (GO-Sim) and KEGG enrichment similarity (KEGG-Sim). Traditional drug similarity involves drug target similarity (Target Sim), chemical similarity (Chemical Sim) and side-effect similarity (Side effect Sim)