Table 2.

Indications for adjuvant chemotherapy in early-stage breast cancer^*

Triple-negative

HER2-positive

Low hormone receptor status

High Ki-67 status

Histologic grade 3 tumors

High 21-gene recurrence score

High-risk 70-gene signature

Involvement ≥3 lymph nodes

ER-positive, HER2-negative†

*From references Goldhirsch et al⁹ and Burkard et al.¹⁰

†If tumor size >1 cm or there is lymph node involvement.