Table 2.
Studies that have evaluated the association between BMI and human ADSC and adipocyte functionality (ordered by sample size)
| Reference | LOE | Sample size (n) | Subjects | Female (n or %) | BMI (kg/m2) | BMI: subset categories (n) | Outcome: ADSC yield | Outcome: differentiation potential |
|---|---|---|---|---|---|---|---|---|
| Van Harmelan et al. 2003 [34] | 2 | 189 | Healthy women undergoing breast reduction procedure | 100% | 19.7–39.7 | <25 kg/m2 (57) 25–29.9 kg/m2 (96) > 30 kg/m2 (35) | Significant positive association between BMI and ADSC count per body Significant negative correlation between BMI and ADSC per gram of adipose tissue | Significant negative correlation between BMI and ADSC differentiation potential |
| Faustini et al. 2010 [29] | 2 | 125 | Men had more resected samples; women had more lipoaspirates. Donor sites also varied with gender. Therefore, analyses were stratified for gender | 88 | 25.33 ± 3.44 (M) 26.68 ± 5.4 (F) | - | No significant correlation between ADSC yield and BMI in both males and females | - |
| Yu et al. 2010 [36] | 2 | 64 | Elective liposuction surgery or abdominoplasty | 90.6% | 18.3–37.2 (27.0 ± 3.8) | <25 kg/m2 (6) 25–29.9 kg/m2 (6) > 30 kg/m2 (6) | Donor BMI was associated with increased ADSC yield per unit volume of lipoaspirate tissue | No significant difference in ADSC proliferation in subset analyses (n = 6 each cohort) |
| Harris et al. 2010 [30] | 2 | 50 | Lipoaspirate from abdomen in patients undergoing elective vascular procedures. Multiple co-morbidities | 36% | <30 kg/m2 (30) ≥ 30 kg/m2 (20) | No significant correlation between ADSC yield and BMI | - | |
| Isakson et al. 2009 [49] | 2 | 51 | Abdominal subcutaneous tissue: needle biopsy (45) and bariatric surgery (6) | - | 19.3–54.8 (28.8 ± 2.2) | - | - | Significant negative correlation between BMI and adipogenic differentiation potential |
| Mojallal et al. 2011 [31] | 2 | 42 | Elective liposuction—abdomen | 100% | 20–35.6 (26.3) | ≤25 kg/m2 (15) > 25 kg/m2 (27) | No significant correlation between BMI and ADSC yield | Tendency toward negative correlation between BMI and proliferation rate (not statistically significant) |
| Padoin et al. 2008 [32] | 2 | 25 | Elective liposuction—multiple donor sites | 100% | 20–37 (26.2 ± 4.4) | - | No significant correlation between BMI and ADSC yield (adjusted for donor site) | - |
| Geissler et al. 2014 [27] | 2 | 24 | Elective liposuction—multiple donor sites | 100% | 20.4–34.5 | <25 kg/m2 (13) ≥ 25 kg/m2 (11) | No significant correlation between BMI and ADSC yield (adjusted for donor site) | - |
| Aust et al. 2004 [28] | 2 | 18 | Elective liposuction—hips and thighs | 87.5% | 20.5–29.3 (24.9 ± 2.7) | - | Significant negative correlation between BMI and ADSC yield | - |
| Roldan et al. 2011 [52] | 2 | 16 | Omental adipose tissue: 12 obese patients undergoing bariatric study and 4 lean patients undergoing abdominal surgery | 50% | - | ≤25 kg/m2 (4) 40–55 (6) ≥ 55 (6) | - | Significant negative correlation between BMI and ADSC proliferation Positive correlation between BMI, premature senescence and cytokine secretion |
| Frazier et al. 2013 [48] | 2 | 12 | Cryopreserved ASCs isolated from lipoaspirate from abdomen | 100% | 22.2 ± 1.79 | ≤25 kg/m2 (6) > 25 kg/m2 (6) | - | Significant negative correlation between BMI ADSC proliferation and osteogenic differentiation potential |
| Perez et al. 2013 [50] | 2 | 10 | Adipose tissue from patients after bariatric surgery | 100% | 20.0 ± 2.1 (<25 kg/m2) 34.0 ± 3.1(>30 kg/m2) | <25 kg/m2 (5) > 30 kg/m2 (5) | - | Significant negative correlation between BMI and ADSC differentiation and migration capabilities |
| Perez et al. 2015 [51] | 2 | 10 | Adipose tissue from patients after bariatric surgery | 100% | - | <22 kg/m2 (5) > 30 kg/m2 (5) | Significant negative correlation between BMI and ADSC yield | Significant negative correlation between BMI and ADSC proliferation Significant changes seen in telomerase activity and DNA telomere length leading to reduced self-renewal capacity |
| Yoshimura et al. 2006 [35] | 2 | - | 100% | - | No significant correlation between ADSC yield and BMI | - |
ADSC adipocyte derived stem cell, BMI body mass index, F female, LOE Level of Evidence, n number