Table 1.

Reported cases of hypophysitis in the dog

Signalment	Presentation	Treatment	Outcome	Diagnosis	Reference
9 y MN Samoyed	3 y dermatitis and blepharitis	Medical therapy	Euthanasia	Lymphoplasmacytic adenohypophysitis and sebaceous adenitis	[10]
4.5 y FE Great Pyrenees	2 m progressive paresis and pelvic limb muscle atrophy	Prednisolone Levothyroxine	Euthanasia	Lymphocytic adenohypophysitis and adrenalitis with polyendocrine syndromea	[8]
10 y FE Crossbreed	3 m progressive anorexia and weight loss; gastroenteritis, pyrexia	IVFT Ranitidine Fenbendazole	Sudden death	Lymphoplasmacytic adenohypophysitis with adrenal insufficiency and giardiasis	[11]
8 y ME German Longhaired Pointer	Acute onset PUPD, exercise intolerance, dull mentation and hair coat	Desmopressin Hypophysectomy Mannitol	Euthanasia	Lymphocytic hypophysitis with central diabetes insipidus	[5]
6 y MN Scottish Terrier	One week progressive lethargy, anorexia, pelvic limb ataxia	Not reported	Death after acute severe hypernatraemia	Lymphocytic panhypophysitis with extension to hypothalamus and polyendocrine syndromeb	[4]

^ahypothyroidism and hypoadrenocorticism; ^bsuspected primary hypoadrenocorticism and secondary hypothyroidism; PUPD polyuria/polydipsia, IVFT intravenous fluid therapy, MN neutered male, FN neutered female, ME intact male, FE intact female. Note that the sellar xanthogranuloma with polyendocrine syndrome in a 7 year-old neutered male Standard Poodle reported by Cramer et al. [9] is not included in the table due to current controversy regarding the classification of this as a separate entity from hypophysitis, based on pathogenesis