Table 2.
Results of the univariate and multivariate analyses of prognostic factors for OS
| Univariate analysis | Multivariate analysis | |||||
|---|---|---|---|---|---|---|
| Characteristic | MST (mos) | 5-y OS (%) | p-value | HR | 95% CI | p-value |
| Age | 0.394 | |||||
| < 60 y | 31.3 | 29.8 | ||||
| ≥ 60 y | 37.9 | 35.0 | ||||
| Sex | 0.850 | |||||
| Male | 34.6 | 30.0 | ||||
| Female | 36.7 | 35.1 | ||||
| ECOG performance status | 0.987 | |||||
| 0 | 36.7 | 30.0 | ||||
| 1 | 34.0 | 34.0 | ||||
| Weight loss | 0.593 | |||||
| ≤ 5% | 37.9 | 32.5 | ||||
| > 5% | 31.6 | 25.0 | ||||
| Smoking status | 0.364 | |||||
| Smokers | 34.6 | 25.8 | ||||
| Nonsmokers | 36.7 | 35.7 | ||||
| Tumor stage | 0.005 | 0.033 | ||||
| 1 | 43.8 | 50.0 | 0.456 | 0.167–1.248 | 0.126 | |
| 2 | 40.7 | 35.4 | 0.441 | 0.237–0.818 | 0.009 | |
| 3 | 15.9 | 6.7 | ||||
| Number of N2 station | 0.029 | 0.654 | 0.387–1.104 | 0.112 | ||
| Single | 49.3 | 38.2 | ||||
| Multiple | 26.9 | 25.0 | ||||
| Postoperative chemotherapy | 0.629 | |||||
| Yes | 34.2 | 31.5 | ||||
| No | 43.8 | 36.4 | ||||
| Postoperative radiotherapy | 0.318 | |||||
| Yes | 31.3 | 22.2 | ||||
| No | 40.7 | 34.7 | ||||
| MiR-29c expression | <0.001 | 3.694 | 2.106–6.479 | <0.001 | ||
| Low | 25.1 | 6.8 | ||||
| High | 68.9 | 58.1 | ||||
Abbreviations: OS overall survival, MST median survival time, mos months, HR hazard ratio, CI confidence interval