Table 3.

Sofosbuvir and velpatasvir for treatment-naïve and experienced patients

Treatment stage	Genotype	Recommendation
Initial treatment of chronic hepatitis C	1, 2, 3, 4, 5, 6	12 weeks treatment duration for patients with genotypes 1–6, including patients with compensated cirrhosis
Retreatment of chronic hepatitis C	1, 2, 3, 4, 5, 6	Treatment experienced, including compensated cirrhosis with HCV genotypes 1a, 1b, and 2, will have 12 weeks of therapy HCV genotype 3: 24 weeks total treatment duration with weight-based ribavirin regardless of cirrhosis state HCV genotypes 4, 5, 6: treatment experienced, including compensated cirrhotics, need 12 weeks with weight-based ribavirin

Abbreviation: HCV, hepatitis C virus.