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. Author manuscript; available in PMC: 2017 Dec 1.
Published in final edited form as: Trends Mol Med. 2016 Oct 27;22(12):1035–1046. doi: 10.1016/j.molmed.2016.10.004

Figure 3.

Figure 3

An Interchromosomal Interaction Drives TAL1 Transcription in T-ALL Cells. Representation of the contact detected by 4C between the TAL1 promoter on chromosome 1 and the TIL16 enhancer on chromosome 16. This interchromosomal interaction depends on expression of the c-MAF transcription factor, which binds to sequences within both TIL16 and the TAL1 promoter. An intrachromsomal contact between CTCF sites downstream of TAL1 is observed by 3C. This presumably represents a CTCF-mediated structural loop.