Figure 4.

Altered microbiota composition in SHP‐2^IEC‐KO mice. Taxonomic microbiota composition at phylum level in SHP‐ 2^IEC‐KO and control littermates at the age of 4 days (A), 2 weeks (B), and 1 month (C) was determined by deep sequencing analysis. PCoA ordination plot constructed on the Bray Curtis distance matrix calculated on normalized data from SHP‐2^IEC‐KO and control littermates at the age of 2 weeks (D) and 1 month (E). Alpha‐diversity (within community) measures (richness, measured as observed species and diversity measured as Shannon's diversity index) in SHP‐ 2^IEC‐KO and control littermates at the age of 2 weeks (F) and 1 month (G). (H) Changes at genus level in SHP‐2^IEC‐KO and control littermates at the age of 2 weeks and 1 month (n ≥ 7 per group). *P ≤ 0.05. The error bars indicate SEM.