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Model of folding in hCRBPII, which hypothesizes that an open monomer folding intermediate leads to domain swapped dimerization and requires proper relative orientation of the two halves of the open monomer: Left, the two A chains of an asymmetric dimer cannot dimerize due to severe steric clashes. Right, the A and B chains of the asymmetric dimer fit perfectly to form a stable, asymmetric dimer.
