Table 1.
Characteristic | DL1 | DL2 | DL3 | DL4 | DL5 | DL6 | All Dose Levels |
---|---|---|---|---|---|---|---|
N = 3 | N = 6 | N = 6 | N = 7 | N = 6 | N = 4 | N = 32 | |
Age – yr | |||||||
Median | 65 | 57 | 59 | 56 | 57 | 58 | 58 |
Range | 62–86 | 50–75 | 40–78 | 42–74 | 47–78 | 56–65 | 40–86 |
Sex – no (%) | |||||||
Male | 2 (66) | 0 | 3 (50) | 3 (43) | 0 | 0 | 8(25) |
Female | 1 (33) | 6 (100) | 3 (50) | 4 (57) | 6(100) | 4(100) | 24(75) |
ECOG – no (%) | |||||||
0 | 0 | 0 | 3 (50) | 2 (29) | 4(66) | 2(50) | 11(34) |
1 | 3 (100) | 6 (100) | 3 (50) | 5 (71) | 2(33) | 2(50) | 21(66) |
Primary Site of Disease –no (%) | |||||||
Non-Gyn | 3(100) | 2(33) | 3(50) | 6(86) | 0 | 0 | 14(44) |
Ovary or Fallopian | 0 | 4 (66) | 3(50) | 1 (14) | 6(100) | 4(100) | 18(56) |
Stage of Disease | |||||||
II | 0 | 0 | 1(17) | 0 | 1(17) | 0 | 2(6) |
III | 0 | 0 | 0 | 1(14) | 2(33) | 3(75) | 6(19) |
IV | 3(100) | 6(100) | 5(83) | 4(57) | 2(33) | 1(25) | 21(66) |
Unknown | 2(28) | 1(17) | 0 | 3(9) | |||
# Prior Tx | |||||||
1 | 2(66) | 3(50) | 1(17) | 2 (29) | 1(17) | 0 | 9(28) |
2-3 | 0 | 0 | 3(50)) | 5 (71) | 1(17) | 0 | 9(28) |
4+ | 1(33) | 3(50) | 2(33) | 0 | 4(66) | 4(100) | 14(44) |