B6.ApcMin/+ mice were fed the LFD or HFD with coconut (purple), corn (green), or olive (blue) oil as a source of fat for 60 days. The final body weight (A), HOMA-IR (B), total number of polyps (C) and polyp mass (D) were assessed after Day 60 of diet treatment. Values represent means ± s.e.m. (n=7–54 males/group). *P<0.05, **P<0.01, ***P<0.001 in relation to equivalent LFD-fed group. ###P<0.001 in relation to HFDCoco- or HFDCorn-fed groups.