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. Author manuscript; available in PMC: 2017 Oct 1.
Published in final edited form as: Mol Cancer Res. 2016 Aug 17;14(10):953–965. doi: 10.1158/1541-7786.MCR-16-0153

Figure 4. Inflammation and intestinal neoplasia are triggered soon after exposure to HFD- the 3 days study.

Figure 4

B6.Apc+/+ and B6.ApcMin/+ mice were fed the LFDCoco or HFDCoco for 3 days. Final body weight (A) and HOMA-IR (B) were measured at Day 3 of treatment. Intestinal polyp number (C) and mass (D) were analyzed. Circulating levels of C5a (E) and adiponectin (F) were measured in plasma. Levels of anti- and pro-inflammatory mediators implicated in inflammation and cancer- C5a (G), IL-6 (H), VEGF (I), IL-23 (J), TNF-α (K), and IL-10 (L) were measured in the intestine of B6.Apc+/+ or B6.ApcMin/+ at Day 3 of treatment. Values represent means ± s.e.m. (A–F, n=6–9 males/group; G–L, n=3–5). *P<0.05, **P<0.01, ***P<0.001 in relation to the corresponding LFD-fed group.