Selective toxicity of a GPI analogue (compound 1) to bloodstream from T. brucei. Parasites were cultured in the presence of 0 (control), 10, 20, 30 and 40 μM compound 1. Viable cells were estimated after 2, 4, 6 and 8 h and normalized to a percentage of the control cultures (values are means of at least nine separate determinations and standard errors are ⩾±5%).