Table 4.
Selection of differentially hypermethylated genes in neural tissues from NTD cases as compared to controls for validation using Sequenom MassARRAY in stage 1.
| Pathway | Gene symbol | Gene full name | Location |
|---|---|---|---|
| Axon guidance | FYN | FYN proto-oncogene, Src family tyrosine kinase | 6q21 |
| Metabolism of xenobiotics by cytochrome P450 | ALDH1A3 | aldehyde dehydrogenase 1 family member A3 | 15q26.3 |
| CYP1B1 | cytochrome P450 family 1 subfamily B member 1 | 2p22.2 | |
| MGST1 | microsomal glutathione S-transferase 1 | 12p12.3-p12.1 | |
| Heparan sulfate biosynthesis | EXTL3 | exostosin like glycosyltransferase 3 | 8p21 |
| Regulation of actin cytoskeleton | BDKRB2 | bradykinin receptor B2 | 14q32.2 |
| CHRM1 | cholinergic receptor muscarinic 1 | 11q13 | |
| CYFIP2 | cytoplasmic FMR1 interacting protein 2 | 5q33.3 | |
| FGF19 | fibroblast growth factor 19 | 11q13.1 | |
| FGFR2 | fibroblast growth factor receptor 2 | 10q26 | |
| PIK3R1 | phosphoinositide-3-kinase regulatory subunit 1 | 5q13.1 | |
| TIAM2 | T-cell lymphoma invasion and metastasis 2 | 6q25.2 | |
| Tight junction | CTNNA1 | catenin alpha 1 | 5q31.2 |
| MYH2 | myosin, heavy chain 2, skeletal muscle, adult | 17p13.1 | |
| PPP2R2B | protein phosphatase 2 regulatory subunit B, beta | 5q32 | |
| Wnt signaling pathway | CAMK2A | calcium/calmodulin dependent protein kinase II alpha | 5q32 |
| MMP7 | matrix metallopeptidase 7 | 11q22.2 | |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 3q26.32 | |
| VANGL2 | VANGL planar cell polarity protein 2 | 1q23.2 | |
| WNT8B | Wnt family member 8B | 10q24 |