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. 2016 Dec 9;12(2):105–112. doi: 10.1080/15592294.2016.1267886

Figure 1.

Figure 1.

Panobinostat posttranscriptionally enhances Dicer protein expression. A. JAR cells treated with increasing doses of Panobinostat for 24 h were harvested, lysed, and probed for expression of Dicer, Argonaute-2, acetylated histone 3, Caspase-3, cleaved Caspase-3, and β-actin via Western blot. Data represent three independent experiments. B. Data from A quantified from three independent experiments. C. RNA was harvested from the previous cell treatments and Dicer and β-actin mRNA levels were assessed via quantitative real-time RT-PCR. D. JAR cells treated with 25 nM Trichostatin A were harvested and probed for expression of Dicer, acetylated histone 3, and β-actin via Western blot. The data represent three independent experiments. E. Data from D quantified from three independent experiments. Error bars ± SEM, *P < 0.05, **P < 0.005, ***P < 0.0005.