Figure 3.

Panobinostat reduces the proteasomal degradation of Dicer. A. JAR cells treated for 24 h with Bortezomib, Panobinostat, or Bortezomib + Panobinostat were harvested and probed for expression of Dicer, acetylated histone 3, Caspase-3, cleaved Caspase-3, and β-actin via Western blot. The data represent three independent experiments. B. Data from A quantified from three independent experiments combined and the statistics are displayed in the table. Error bars ± SEM, *P < 0.05, **P < 0.005.