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Bortezomib decreases Dicer activity. A. 20 µg of protein lysates from JAR cells +/− 24 h of Bortezomib treatment were used in the Dicer activity assay and the amount of pre-miR-124a and mature-miR-124a were quantified. B. Dicer's relative specific activity was calculated using the ratio of mature-miR-124a produced to Dicer protein expression in a lysate. The data represent three independent experiments. Error bars ± SEM, **P < 0.005.
