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. 2004 Oct 28;23(23):4527–4537. doi: 10.1038/sj.emboj.7600458

Figure 5.

Figure 5

Sliding on hydrophobic patches. The surfaces of the HP and HW helices of the L50 subdomain make variable contacts with the seven-stranded β-sheet, as shown for myosin V MDE rigor-like and post-rigor states (positioned by overlaying the L50 subdomains). Note in particular the sliding of two residues of the β-sheet (Y223 and L436) on the surface of the HW helix near T650, as well as three residues (R240, Y242 and L243; labelled RYL) found near the beginning of the highly conserved U50 linker involved in closing the cleft.