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. 2017 Feb 28;14(2):e1002248. doi: 10.1371/journal.pmed.1002248

Fig 4. Effect of sustained serelaxin infusion on AKT/eNOS/NO signaling in cirrhotic rat kidney.

Fig 4

Quantification of p-eNOS/eNOS and p-AKT/AKT in whole kidney extracts from 72-h serelaxin- or vehicle-treated 16-wk CCl4 and 4-wk bile duct ligation (BDL) rats (n = 4) (A–F). Data presented as mean ± standard error of the mean (SEM), analyzed by unpaired t-test (*p < 0.05; **p < 0.01; ***p < 0.001). NOS activity in whole kidney extracts from CCl4 (G) and BDL (H) rats treated with serelaxin or vehicle (n = 6–8). Data presented as mean ± SEM, analyzed by unpaired t-test (*p < 0.05; **p < 0.01). Renal blood flow (RBF; I) and glomerular filtration rate (GFR; J) in 16-wk CCl4 rats co-treated with L-NG-nitroarginine methyl ester (L-NAME) (n = 4–8). Data presented as mean ± SEM, analyzed by one-way ANOVA with post hoc Bonferroni correction (*p < 0.05; **p < 0.01; ***p < 0.001). OO, olive oil.