Table 1. Baseline demographic and clinical characteristics of study participants at screening.
| Characteristic | Serelaxin (n = 20) | Terlipressin (n = 20) |
|---|---|---|
| Sex, n (percent) male/female | 16 (80%)/4 (20%) | 16 (80%)/4 (20%) |
| Age (years)* | 60 (57, 64) | 55 (51, 58) |
| Body mass index (kg/m2)* | 30 (28, 32) | 28 (25, 31) |
| Alcohol use, n (percent) A/L/O† | 13 (65%)/7 (35%)/0 | 10 (50%)/4 (20%)/6 (30%) |
| Albumin (g/l)* | 40 (37, 43) | 41 (39, 42) |
| Bilirubin (μmol/l)* | 12 (8, 18) | 19 (12, 29) |
| INR* | 1.2 (1.1, 1.3) | 1.2 (1.1, 1.3) |
| Creatinine (μmol/l)* | 73 (66, 81) | 66 (59, 73) |
| eGFR (ml/min/1.73 m2)* | 90 (78, 103) | 104 (89, 120) |
| Platelet count (× 10−3)* | 77 (42, 143) | 95 (68, 134) |
| Mean arterial pressure (mm Hg)* | 108 (101, 115) | 105 (98, 112) |
| Heart rate (beats/min)* | 71 (67, 75) | 65 (61, 70) |
| Child-Pugh score* | 5 (5, 6) | 5 (5, 6) |
| MELD score* | 9 (8, 10) | 10 (8, 11) |
| Previous variceal bleed, n (percent) | 7 (35%) | 3 (15%) |
| Splenomegaly, n (percent) | 13 (65%) | 15 (75%) |
*Data expressed as mean (95% CI), except mean arterial pressure and heart rate, which are expressed as geometric mean ± 95% CI.
†A = abstinent, L = less than one drink per day, O = one to two drinks per day.
eGFR, estimated glomerular filtration rate; INR, international normalized ratio; MELD, Model for End-Stage Liver Disease.