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. 2017 Feb 28;12(2):e0173112. doi: 10.1371/journal.pone.0173112

Table 1. Patient characteristics and technical parameters.

Number (n), mean +/- SD or median with 25% and 75% percentile
patients (n) 30 (100%)
male / female (n) 23 / 7 (77% / 23%)
age, years (mean +/- SD) 60.2 +/- 14.99
MGMT status (n = 27)
 methylated 13 (48%)
 unmethylated 14 (52%)
IDH status (n = 21)
 wildtype (n) 20 (95%)
 mutation (n) 1 (5%)
Chemotherapy
 Temozolomide (n) 26 (87%)
 Bevacizumab (n) 2 (7%)
Radiotherapy
 received (n) 30 (100%)
 initial dose in Gy (n = 28) 60 (60–60)
MRI scans (n)
 3 6
 4 3
 5 7
 6 7
 7 4
 8 1
 10 1
 12 1
CV segmentations (n) 165
 CV in ml (median) 2.80 (0.30–10.90)
 dCV in ml (median) 0.00 (-2.60–3.40)
 sCV in ml (median) 1.49 (0.11–6.24)
FV segmentations (n) 165
 FV in ml (median) 50.10 (26.20–92.40)
 dFV in ml (median) 0.80 (-16.10–19.30)
 sFV in ml (median) 17.22 (7.48–35.18)
RC—MC categories
 0 “initial diagnosis” (n) 6 (3.6%)–6 (3.6%)
 1 “postoperative” (n) 33 (20.0%)–33 (20.0%)
 2 “regression” (n) 11 (6.7%)–11 (6.7%)
 3 “stable” (n) 19 (11.5%)–17 (10.3%)
 4 “uncertain progression” (n) 21 (12.7%)–15 (9.1%)
 5 “progression” (n) 75 (45.5%)–83 (50.3%)

SD = standard deviation, CV = contrast enhancing volume, dCV = absolute change of CV between two consecutive MRI time points, sCV = regional, segmentation-based subtractions of CV between two consecutive MRI time points, FV = FLAIR hyperintense volume, dFV = absolute change of FV between two consecutive MRI time points, sFV = regional, segmentation-based subtractions of FV between two consecutive MRI time points, RC = radiologic consensus, MC = multidisciplinary consensus.