Figure 2.

Histone-methylation enzymes in colorectal cancer (CRC). Enzymes of histone methyltransferase (HMT) and histone demethylase (HDM) are plotted in a polygenetic tree based on sequence homology. The gene name of each enzyme is highlighted by different colors according to its role in CRC: orange, oncoproteins and blue, tumor suppressor. Gene name in bold represents a validated target. If the enzyme has potent chemical probes, it is labeled with ‘C’ in a circle; if it has crystal structure(s) which contains the catalytic domain, it is labeled with ‘S’ in a circle.

HMTs, histone methyltransferases; HDMs, histone demethylases.