(A) Expression of integrin α6 in papillary lysates from a 3-day old Itga6flox/flox and Hoxb7cre:Itga6flox/flox mice was analyzed by Western blotting analysis. α6 is indicated by the arrowhead. (B–I) Morphology of H&E stained kidney sections from Itga6flox/flox and Hoxb7cre:Itga6flox/flox mice at 2 months (magnification 40×, scale bar =500um) (B, C), 6 months (magnification 40×, scale bar =500um), (D, E) and 10 months of age (F, G) (magnification 40×, scale bar =500um) and (H, I) (magnification 200×, scale bar =100um).