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. 2017 Feb 20;127(3):1099–1114. doi: 10.1172/JCI90086

Figure 9. Liver endothelial GATA4 prevents peri-sinusoidal ECM deposition.

Figure 9

(A) Sirius red staining in the liver of Stab2-Cre Gata4fl/fl embryos at E13.5 (n = 3). Scale bars: 10 μm. (B) IHC of collagen I, collagen III, collagen IV, and tenascin C in the liver of Stab2-Cre Gata4fl/fl embryos at E13.5 (n = 3). Scale bars: 50 μm. (C) Expression of LAMA4 in the liver of Stab2-Cre Gata4fl/fl embryos at E11.5 (n = 3). IHC of LAMA4. Scale bars: 100 μm (overview) and 50 μm (magnification) (left panels). Co-IF of CD31 with LAMA4 or collagen 15a1. Scale bars: 20 μm (middle panels). Co-IF of LAMA4 with COL15A1 or desmin. Scale bars: 10 μm (right panels).