Table 1. Summary of Studies Reporting Cases of Cerebral Radiation Necrosis Treated With Bevacizumab.

Author, year of publication	Title of the study	Institution	Journal of publication	Cases	Age	Gender
Gonzalez et al, 2007 [25]	Effect of bevacizumab on radiation necrosis of the brain	The University of Texas M. D. Anderson Cancer Center, Houston, USA	Int. J. Radiation Oncology Biol. Phys.	8	54	4 M 4 F
Wong et al, 2008 [26]	Bevacizumab reverses cerebral radiation necrosis	Brain Tumor Center & Neuro-Oncology Unit, Deaconess Medical Center, Boston, USA	J Clin Oncol.	1	43	F
Liu et al, 2009 [31]	Bevacizumab as therapy for radiation necrosis in four children with pontine gliomas	Dpt of Radiation Oncology, University of Colorado Denver, Aurora, USA	Int. J. Radiation Oncology Biol. Phys.	3	-	1 F 2 M
Torcuator et al, 2009 [27]	Initial experience with bevacizumab treatment for biopsy confirmed cerebral radiation necrosis	Dpt of Neurosurgery, Henry Ford Hospital, Detroit, USA	J Neurooncol.	6	48	3 F 3 M
Jeyaretna et al, 2011 [42]	Exacerbation of cerebral radiation necrosis by bevacizumab	Massachusetts General Hospital, Boston, USA	J Clin Oncol.	1	35	M
Benoit et al, 2011 [30]	Favorable outcome with bevacizumab after poor outcome with steroids in a patient with temporal lobe and brainstem radiation necrosis	Hospices Civils de Lyon, Neurologie, Lyon, France	J Neurol.	1	38	F
Matuschek et al, 2011 [33]	Bevacizumab as a treatment option for radiation-induced cerebral necrosis	Dpt of Radiation Oncology, University Hospital Dusseldorf, Dusseldorf, Germany	Strahlenther. Onkol.	1	19	M
Levin et al, 2011 [35]	Randomized double-blind placebo-controlled trial of bevacizumab therapy for radiation necrosis of the CNS	Dpt of Neuro-Oncology, University of Texas M. D, Houston, Texas, USA	Int. J. Radiation Oncology Biol. Phys.	7	47	4 M 3 F
Nonoguchi et al, 2011 [12]	The distribution of vascular endothelial growth factor-producing cells in clinical radiation necrosis of the brain: pathological consideration of their potential roles	Department of Neurosurgery, Osaka Medical College, Takatsuki, Japan	J. Neurooncol.	6	58	2 M 4 F
Sanborn et al, 2011 [32]	Treatment of steroid refractory, Gamma Knife related radiation necrosis with bevacizumab: case report and review of the literature	University of Pennsylvania, Dpt of Neurosurgery, United States	Clinical Neurology and Neurosurgery	1	38	M
Arratibel-Echarren et al, 2011 [28]	Use of bevacizumab for neurological complications during initial treatment of malignant gliomas	Dpt of Neuro-Oncology, University of Pennsylvania, Philadelphia, USA	Neurologia	4	42	4 M
DeSalvo et al, 2012 [29]	Radiation necrosis of the pons after radiotherapy for nasopharyngeal carcinoma: diagnosis and treatment	Harvard Medical School, Boston, USA	Radiology Case	1	57	M
Wang et al, 2012 [34]	Reversal of cerebral radiation necrosis with bevacizumab treatment in 17 Chinese patients	Dpt of Radiation Oncology, Huashan Hospital, Fudan University, Shanghai, China	European Journal of Medical Research	17	48	13 M 4 F
Furuse et al, 2013 [38]	Bevacizumab treatment for symptomatic radiation necrosis diagnosed by amino acid PET	Dpt of Neurosurgery, Osaka Medical College, Takatsuki, Osaka, Japan	Jpn J Clin Oncol	11	57	6 M 5 F
Boothe et al, 2013 [36]	Bevacizumab as a treatment for radiation necrosis of brain metastases post stereotactic radiosurgery	Dpt of Radiology and Brain Tumor, Memorial Sloan-Kettering Cancer Center, New York, USA	Neuro-Oncology	11	58	4 M 7 F
Alessandretti et al, 2013 [40]	Low-dose bevacizumab is effective in radiation-induced necrosis	Dpt of Oncology, Hospital Sao Jose, Sao Paulo, Brazil	Case report in Oncology	2	49	F
Bostrom et al, 2014 [37]	Bevacizumab treatment in malignant meningioma with additional radiation necrosis	University of Bonn Medical Center, Bonn	Strahlenther. Onkol.	1	80	F
Delishaj et al, 2015 [39]	The effectiveness of bevacizumab in radionecrosis after radiosurgery of a single brain metastasis	Dpt of Radiotherapy, University Hospital of Pisa, Italy	Rare Tumor	1	73	F
Sadraei et al, 2015 [41]	Treatment of cerebral radiation necrosis with bevacizumab: the Cleveland Clinic experience	Brain Tumor Neuro-Oncology Center, Radiation Oncology and Solid Tumor, Cleveland	American Journal of Clinical Oncology	24	57	9 M 15 F
Zhuang et al, 2015 [44]	Exploration of the recurrence in radiation brain necrosis after bevacizumab discontinuation	Dpt of Radiotherapy, Tianjin Medical University Cancer, Tianjin, China	Oncotarget.	14	56	6 M 8 F
Xiang-Pan et al, 2015 [43]	Bevacizumab alleviates radiation-induced brain necrosis: a report of four cases	Dpt of Oncology, Renmin Hospital of Wuhan University, Wuhan, China	J. Cancer Res. Ther.	4	58	3 F 1 M
Total number of cases included in the review				125		63 M 62 F

M: male; F: female; Dpt: department.