Table 2. Summary of Studies Reporting Cases of Cerebral Radiation Necrosis Treated With Bevacizumab.
| Author, year of publication | Bevacizumab treatment | No. of cycles (median) | Follow-up (months, median) | RN T1 post-contrast reduction (mean) | RN FLAIR reduction (mean) |
|---|---|---|---|---|---|
| Gonzalez et al, 2017 [25] | 5 mg/kg every 2 weeks or 7.5 mg/kg every 3 weeks | 2 - 4 | 8 | 51% | 66 |
| Wong et al, 2008 [26] | 5 mg/kg every 2 weeks | 4 | 6 | - | - |
| Liu et al, 2009 [31] | 10 mg/kg every 2 weeks | 4 | 7 | - | - |
| Torcuator et al, 2009 [27] | 10 mg/kg every 2 weeks | 2 - 4 | 6 | 79% | 49% |
| Jeyaretna et al, 2011 [42] | 5 mg/kg every 2 weeks | 4 | 5 | - | - |
| Benoit et al, 2011 [30] | 5 mg/kg every 2 weeks | 4 | 12 | - | - |
| Matuschek et al, 2011 [33] | 10 mg/kg every 2 weeks | 6 | 5 | 100% | |
| Levin et al, 2011 [35] | 7.5 mg/kg every 2 - 3 weeks | 4 | 10 | 63% | 59% |
| Nonoguchi et al, 2011 [12] | - | - | - | - | - |
| Sanborn et al, 2011 [32] | 10 mg/kg every 2 weeks | - | 4 | - | - |
| Arratibel-Echarren et al, 2011 [28] | - | - | - | ||
| DeSalvo et al, 2012 [29] | 10 mg/kg every 2 weeks | - | - | - | - |
| Furuse et al, 2013 [38] | 5 mg/kg every 2 weeks | 3 | 14.4 | 65% | 65.5% |
| Wang et al, 2012 [34] | 7.5 mg/kg every 2 weeks | 2 - 6 (4) | 6 | 54.9% | 48.4% |
| Furuse et al, 2013 [38] | 5 mg/kg every 2 weeks | 3 | 14.4 | 65% | 65.5% |
| Boothe et al, 2013 [36] | 10 mg/kg every 2 weeks | 6 | - | 56.7% | 52.7% |
| Alessandretti et al, 2013 [40] | 5 mg/kg every 2 weeks 7.5 mg/kg every 4 weeks |
- | 10 | - | - |
| Bostrom et al, 2014 [37] | 5 mg/kg every 2 weeks | 4 | 4 | - | - |
| Delishaj et al, 2015 [39] | 7.5 mg/kg every 2 weeks | 4 | 8 | - | - |
| Sadraei et al, 2015 [41] | 11% 10 mg every 2 weeks or 15 mg/kg every 3 weeks 13% 5 mg/kg every 2 weeks or 7.5 mg/kg every 3 week |
6 | 8 | 48.1% | 53.7% |
| Zhuang et al, 2015 [44] | 5 mg/kg every 3 - 4 weeks | 3 | 12 | 64.2% | - |
| Xiang-Pan et al, 2015 [43] | 7.5 mg/kg every 3 weeks | 2 | - | - | - |