Skip to main content
. Author manuscript; available in PMC: 2018 Mar 1.
Published in final edited form as: Stroke. 2017 Mar;48(3):747–753. doi: 10.1161/STROKEAHA.116.015204

Fig 5.

Fig 5

MiR-17-92 cluster elevated MSC exosomes negatively regulate the PTEN expression and subsequently activate the PI3K/Akt/mTOR signaling pathway. Panel A shows compared with liposome and Ex-Con treatment, Ex-miR-17-92+ treatment significantly downregulated the PTEN protein level in the IBZ (1) and subsequently increased the phosphorylation of Akt (2) and mTOR (3), and then increased the phosphorylation of GSK-3β (4) in the IBZ. Double immunofluorescence staining shows p-GSK-3β locates in the IBZ neurons (B). LP: MCAO rats treated with liposome; EV: MCAO rats treated with Ex-Con; 17-92: MCAO rats treated with Ex-miR-17-92+. *P<0.05, compared to EV. Mean±SE, n=3/group. Scale bar=50 µm.