Skip to main content
. Author manuscript; available in PMC: 2018 Feb 28.
Published in final edited form as: Mol Biosyst. 2017 Feb 28;13(3):489–497. doi: 10.1039/c6mb00672h

Figure 5. Contributions of different enzymes to the observed metabolic alterations.

Figure 5

Out of six known enzymatic changes, different combinations are implemented. When only one enzyme activity is altered, there are six different choices and the corresponding results are put into the column next to the control, which corresponds to a healthy system. Subsequent columns show the results of two (15 different combinations), three (20 different combinations), four (15 different combinations), and five combinatory alterations (6 different combinations). The y-axis represents Jeffreys & Matusita distances, which are normalized to the distance between the true health and disease profiles (see Supplements). Each red horizontal line shows the smallest distance in the corresponding column.