Fig. 10.

HDAC inhibition facilitates IL-10-dependent negative regulation of BMDC function. a Allogeneic T cell expansion was attenuated by treatment with either SAHA or IL-10, and further suppressed by combinatorial treatment with SAHA and IL-10. Expression of IFN-γ (b) or IL-6 (c) was attenuated by treatment with either SAHA or IL-10, and further suppressed by combinatorial treatment with SAHA and IL-10. d Blocking IL-10 signaling significantly improved allogeneic T cell expansion which was mitigated by SAHA plus IL-10 treatment. Data were from 3 independent experiments (mean ± SEM). p values were obtained using an unpaired t test. Syn = Syngeneic cells.