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. Author manuscript; available in PMC: 2018 Mar 1.
Published in final edited form as: Lancet Infect Dis. 2016 Dec 8;17(3):285–295. doi: 10.1016/S1473-3099(16)30474-1

Table 2.

Pooled estimates of case fatality ratios.

Era and age group Datasets Children Deaths Pooled estimate (95% CI) I-squared
Pre-treatment era studies
0–14 years 8 36,472 8,737 21.9% (18.1%, 26.4%) 0.975
 0–4 years1 8 10,239 4,685 43.6% (36.8%, 50.6%) 0.945
 5–14 years 7 26,216 4,046 14.9% (115%, 19.1%) 0.970
Middle-era studies
0–14 years 5 870 100 13.6% (6.7%, 25.4%) 0.883
 0–4 years2 4 651 102 16.5% (11.6%, 23.0%) 0.671
 5–14 years 4 356 28 8.3% (5.6%, 12.3%) 0.104
Recent-era studies
0–14 years5 12 44,514 362 0.9% (0.5%, 1.6%) 0.955
 0–4 years3 6 12,741 118 1.9% (0.5%, 7.1%) 0.967
 5–14 years4 7 12,873 132 0.8% (0.3%, 2.1%) 0.925
1

Includes one study of 0–1 years;

2

Includes one study of 0–6 years;

3

Includes one study of 1–4 years;

4

Includes one study of 11–14 years;

5

Includes one study of 0–15 years