Figure 1.

Time-kill kinetics of PNA-TAT against MRSA Sanger 252. Anti-rpoA PNA–TAT at 16 μmol/l (tested in triplicate) was incubated for 24 hours at 37°C with shaking and samples were collected for every 2 hours, serially diluted, and plated onto tryptic soy agar. Viable colony forming units per ml were determined after incubation at 37°C for 16 hours. Vancomycin and linezolid (both at 16 μmol/l) were used as positive controls. The results are presented as mean ± SD from two independent experiments. PNA, peptide nucleic acid; MRSA, methicillin-resistant S. aureus.