Table 1.
Overview of case series, individual case report synthesis, and cumulative synthesis
| Article | Sample (n) | Male n (%) | Female n (%) | Age (years) at diagnosis median (IQR) | Cannabis use age (years) of onset median (IQR) | Age (years) at symptom onset median (IQR) | Duration of cannabis use (years) prior to symptom onset median (IQR) | Cannabis use n (frequency of use) | Cyclic vomiting n (%) | Abdominal pain n (%) | Relief with hot bathing % (n/total queried) | Relief with abstinence or reduction % (n/total queried) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Simonetto* [12] | 98 | 66(67) | 32(33) | Mean = 32.3 (±9.9) | na | Mean = 25.3 ±8.9 (n = 98) | 32 (≤1), 42 (2–5), 11 (6–10), 13 (≥11) (n = 98) | 58 (daily), 35 (weekly), 5 (<weekly) (n = 98) | 98 (100) | 84 (86) | 91 (52/57) | 100 (6/6) |
| Allen [6] | 9 | 6(66) | 3(33) | 29 (21–37) (n = 9) | 17 (15.5–18.5) (n = 9) | 22 (15.8–28.3) (n = 9) | 0 (≤1), 5 (2–5), 1 (6–10), 3 (≥11) (n = 9) | 9 (>daily) (n = 9) | 9 (100) | na | 88 (8/9) | 100 (7/7) |
| Soriano-Co [12] | 8 | 5(63) | 3(37) | 34 (31.9–36.2) (n = 8) | 13 (11.3–14.8) (n = 8) | 30.5 (32.4–32.4) (n = 8) | 0 (≤1), 0 (2–5), 1 (6–10), 7 (≥11) (n = 8) | 8 (>daily) (n = 8) | 8 (100) | 8 (100) | 100 (8/8) | 80 (4/5) |
| Wallace b [10] | 31 | 24(78) | 7(22) | 34 (27.8–40.3) (n = 32) | 16 (14–18) (n = 27) | 24 (18.3–29.8) (n = 27) | 2 (≤1), 9 (2–5), 3 (6–10), 12 (≥11) (n = 26) | 28(>daily), 3 (quantity not specified) (n = 31) | 31 (100) | na | 96 (29/30) | 96 (24/25) |
| Sofka [13] | 4 | 3(75) | 1(25) | 25.5 (22.3–28.6) (n = 4) | 16 (14.5–17.5) (n = 4) | 14 (11.5–16.5) (n = 4) | 0 (≤1), 0 (2–5), 3 (6–10), 1 (≥11) (n = 4) | 4 (>daily) (n = −4) | 4 (100) | 4 (100) | 100 (4/4) | 100 (1/1) |
| Patterson [10] | 4 | 4(100) | 0(0) | 29 (24.6–33.4) (n = 4) | 15.5 (14.9–16.1) (n = 4) | 27.5 (18.5–36.5) (n = 4) | 1 (≤1), 1 (2–5), 0 (6–10), 2 (≥11) (n = 4) | 1 (>daily) 3 (daily) (n = 4) | 4 (100) | 3 (75) | 100 (4/4) | 100 (4/4) |
| Nicolson [15] | 4 | 2(50) | 2(50) | 23 (21.3–24.6) (n = 4) | 16.5 (15.6–17.4) (n = 4) | 20 (17.5–22.5) (n = 4) | 1 (≤1), 1 (2–5), 2 (6–10), 0 (≥11) (n = 4) | 1 (>daily) 3 (daily) (n = 4) | 4 (100) | 3 (75) | 100 (4/4) | 100 (2/2) |
| Masri [14] | 4 | 4(100) | 0(0) | 25 (22.6–27.4) (n = 4) | 16 (14–18) (n = 2) | 22 (19.4–24.6) (n = 4) | 0 (≤1), 0 (2–5), 1 (6–10), 0 (≥11) (n = 1) | 1 (>daily), 1 (daily), 0 (weekly), 2 (quantity not specified) (n = 4) | 4 (100) | 4 (100) | 100 (4/4) | 100 (1/1) |
| Individual case report synthesis | 80 | 64(80) | 16(20) | 28.5 (22.6–34.4) (n = 78) | 16 (12–18) (n = 53) | 24 (19.5–28.5) (n = 68) | 11 (≤1), 16 (2–5), 11 (6–10), 13 (≥11) (n = 51) | 26 (>daily), 36 (daily), 6 (weekly), 12 (quantity not specified) (n = 80) | 80 (100) | 66 (82) | 91 (73/80) | 97 (37/38) |
| Cumulative synthesis | 211 | 154 (72.9) | 57 (27.1) | 28 (12) (n = 111) | 16 (4) (n = 84) | 24 (10) (n = 101) | 45 (≤1) 65 (2–5) 30 (6–10) 39 (≥11) (n = 179) | 50 (>daily), 101 (daily), 41 (weekly), 5 (< weekly), 14 (quantity not specified) (n = 211) | 100 (211) | 172 (85.1) (n = 202) | 92.3 (157/170) | 96.8 (62/64) |
aRaw data not available, statistics represented as reported by study authors
bNot included in cumulative synthesis as raw data not available